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The survival and synaptic integration of transplanted dopaminergic (DA) progenitors are essential for ameliorating motor symptoms in Parkinson's disease (PD). Human pluripotent stem cell (hPSC)‐derived DA progenitors are, however, exposed to numerous stressors prior to, and during, implantation that result in poor survival. Additionally, hPSC‐derived grafts show inferior plasticity compared to fetal...
Tissue Programmed Hydrogels
In article number 2105301, David R. Nisbet, Clare L. Parish, and co‐workers show that encapsulating human stem cell‐derived dopamine progenitors within a neural tissue biomimetic hydrogel enhances their engraftment in an animal model of Parkinson's disease. The laminin‐based hydrogel, simultaneously sustains delivery of glial cell‐derived neurotrophic factor and increases...
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