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Tsc-22 was isolated as a TGF-β-inducible gene by differential screening of the mouse osteoblastic cell cDNA library [J Biol Chem 267 (1992) 10219]. tsc-22 mRNA is expressed in almost all organs of mice and humans and its expression is induced in a variety of cell lines by many different factors including TGF-β, phorbol ester, serum, and progestin. tsc-22 encodes a 18-kd protein that contains a leucine...
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