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Immune stimulation inhibits positively motivated behavior and induces depressive illness. To help clarify the mechanism of these effects, neural activity in response to a positive stimulus was examined in brain regions associated with positively motivated activity defined on the basis of prior behavioral studies of central α 1 -adrenoceptor action.Mice pretreated with either lipopolysaccharide...
Rationale Central α1- and α2-adrenoceptors in a number of different brain regions are known to have opposing actions on gross behavioral activity, with the former stimulating and the latter inhibiting activity. Therefore, blockade of α1-receptors may induce inactivity by leading to unopposed α2 activity. Objective The aim of this study was to test if central blockade of α2-receptor function restores...
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