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Aim The purpose of this review is to clarify how central α1-adrenoceptors control behavioral activity under varying conditions of activity and stress. Method The literature is reviewed regarding the behavioral actions of α1-agonists and antagonists, and α2-agonists and antagonists under conditions of high and low baseline activity and stress. Results It was found that α1-receptor stimulation of active...
Rationale Central α1- and α2-adrenoceptors in a number of different brain regions are known to have opposing actions on gross behavioral activity, with the former stimulating and the latter inhibiting activity. Therefore, blockade of α1-receptors may induce inactivity by leading to unopposed α2 activity. Objective The aim of this study was to test if central blockade of α2-receptor function restores...
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