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Objective
This study describes the prevalence of pathogenic germline variants (PGVs) in head and neck cancer patients, the incremental yield compared to a guideline‐based approach to genetic evaluation, and the uptake of family variant testing.
Study Design
Prospective cohort study.
Setting
Three tertiary academic medical centers.
Methods
Germline sequencing using an 84‐gene screening platform...
Purpose
Little is known about disparities in colorectal cancer (CRC) incidence and mortality by community‐level factors such as metropolitan status.
Methods
This analysis utilized data from the Surveillance, Epidemiology, and End Results (SEER) program from Utah. We included patients diagnosed with CRC from 1991 to 2010. To determine whether associations existed between metropolitan/nonmetropolitan...
BACKGROUNDGuidelines recommend that individuals with a first‐degree relative (FDR) diagnosed with colorectal cancer (CRC) or advanced adenoma before age 60 years should undergo colonoscopy starting at age 40 years. The authors quantified the risk of adenomas and CRC in FDRs, second‐degree relatives (SDRs), and third‐degree relatives (TDRs) of patients diagnosed with adenomas and advanced adenomas...
BACKGROUND:Statins and nonsteroidal anti‐inflammatory drugs (NSAIDs) are associated with reduced risk of colorectal cancer (CRC) in some studies. The objective of this study was to quantify the relative risk of inflammatory bowel disease (IBD) as a risk factor for CRC and to estimate whether this risk may be modified by long‐term use of NSAIDs or statins.
METHODS:The Molecular Epidemiology of Colorectal...
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