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In the present work, the Ca2+ dependence of mitochondrial H2O2 elimination was investigated. Mitochondria isolated from guinea pig brain were energized by glutamate and malate and incubated with micromolar concentrations of Ca2+ in the presence of ADP, preventing permeability transition pore formation. After the completion of Ca2+ uptake, mitochondria were challenged with H2O2 (5 μM), then at various...
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