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The Otsuka Long–Evans Tokushima Fatty (OLETF) rat, an animal model of type 2 diabetes, exhibits obesity, hyperglycemia and hyperlipidemia, with late onset of chronic and slowly progressive hyperinsulinemia. In this study, we examined effects of long-term dietary supplementation with the α-glucosidase inhibitor miglitol on the development of diabetes and the reduction of β-cells in the pancreas of...
Postprandial hyperglycemia is thought to cause inflammation in many tissues. In this study, we examined whether the gene expression of inflammatory cytokines/cytokine-like factors in peripheral leukocytes are altered by feeding streptozotocin-treated rats a diet containing an α-glucosidase inhibitor, miglitol.Upregulated gene expression in peripheral leukocytes of streptozotocin-induced hyperglycemic...
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