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The antithrombotic prodrugs ticlopidine and clopidogrel are thienotetrahydro‐pyridine derivatives that are metabolized in the liver to produce thiols that irreversibly block adenosine diphosphate (ADP)‐activated P2Y12 receptors on thrombocytes. In their native, nonmetabolized form, both drugs were reported to act as inhibitors of ectonucleoside triphosphate diphosphohydrolase‐1 (NTPDase1, CD39). CD39...
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