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Extremes of normal neurodevelopmental processes, such as synaptic pruning which culminates with puberty, may be involved in the aetiology of schizophrenia. Saugstad (1994) hypothesises that high synaptic density due to premature arrest of pruning in early maturers predisposes towards affective psychosis, whereas excessive pruning in late maturers results in low synaptic density with increased risk...
Developmental regressive events such as pruning of synapses are implicated in schizophrenia with both over- and under-connectivity models proposed (Randall, Feinberg, Hoffman). Saugstad (1989; 1994) theorised that extremes of normal variation at puberty distinguish affective psychoses (early maturation) from schizophrenia (late maturation). In normal students we have found a three-factor structure...
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