Search results for: Bruce R. Carr

Items from 1 to 20 out of 52 results

article

Impact of body mass index on levels of soluble interleukin-6 receptor in follicular fluid of women undergoing in-vitro fertilization

Laurice Bou Nemer, R. Ann Word, Bruce R. Carr, Orhan Bukulmez

Fertility and Sterility > 2017 > 107 > 3(S) > e7

chapter

Metformin for the Treatment of Polycystic Ovary Syndrome (PCOS)

Satin S. Patel, Victor E. Beshay, Bruce R. Carr

Biennial Review of Infertility > Female Infertility > 21-28

Because of the high prevalence of insulin resistance, there is a growing interest in the application of insulin sensitizing agents in patients with polycystic ovary syndrome (PCOS). Metformin is the most widely prescribed insulin sensitizing agent in patients with PCOS. In this chapter, we address the importance of lifestyle modification as the initial intervention in patients with PCOS. Furthermore,...

article

Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary

M. Max Ezzati, Michael D. Baker, Hatice D. Saatcioglu, Gina M. Aloisio, more

Journal of Assisted Reproduction and Genetics > 2015 > 32 > 12 > 1741-1747

Purpose Foxo3 protein is required in the oocyte nucleus for the maintenance of primordial follicles in a dormant state. PI3K/AKT-dependent phosphorylation of Foxo3 leads to its relocalization to the cytoplasm and subsequent follicular activation. However, the nature of the upstream signals controlling Foxo3 activity and subcellular localization remains unknown. We aimed to study the in vitro effects...

article

Familial 46,XY sex reversal without campomelic dysplasia caused by a deletion upstream of the SOX9 gene

Bala Bhagavath, Lawrence C. Layman, Reinhard Ullmann, Yiping Shen, more

Molecular and Cellular Endocrinology > 2014 > 393 > 1-2 > 1-7

46,XY sex reversal is a rare disorder and familial cases are even more rare. The purpose of the present study was to determine the molecular basis for a family with three affected siblings who had 46,XY sex reversal.DNA was extracted from three females with 46,XY sex reversal, two normal sisters, and both unaffected parents. All protein coding exons of the SRY and NR5A1 genes were subjected to PCR-based...

article

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Mohammad Ezzati, Ovrang Djahanbakhch, Sara Arian, Bruce R. Carr

Journal of Assisted Reproduction and Genetics > 2014 > 31 > 10 > 1337-1347

With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and...

article

Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles

Orkun Tan, Thoa Ha, Bruce R. Carr, Paul Nakonezny, more

Journal of Assisted Reproduction and Genetics > 2014 > 31 > 9 > 1147-1153

Purpose To determine whether postwashed total progressively motile sperm count (TPMSC) obtained by CASA estimates could predict positive pregnancy test result in non-donor IUI cycles. Methods Six thousand eight hundred and seventy one (6,871) IUI cycles with non-donor semen were retrospectively analyzed. Patient, cycle characteristics and prewashed and postwashed semen parameters were included in...

article

Expression and activation of the membrane-cytoskeleton protein ezrin during the normal endometrial cycle

Orkun Tan, Turkan Ornek, Ahmed Fadiel, Kelley S. Carrick, more

Fertility and Sterility > 2012 > 97 > 1 > 192-199.e2

To examine total ezrin expression (ezrin and phospho-ezrin) through the normal endometrial cycle and to correlate ezrin activation and localization with cytologic changes.Experimental laboratory study.University medical centers.Reproductive-age women.A total of 36 samples of normal early, mid-, and late proliferative- and secretory-phase endometrium were studied for immunoreactive total ezrin (ir-T-ezrin)...

article

Virilization from partner's use of topical androgen in a reproductive-aged woman

Anupama S.Q. Kathiresan, Bruce R. Carr, George R. Attia

American Journal of Obstetrics and Gynecology > 2011 > 205 > 3 > e3-e4

A woman presented with virilization symptoms and elevated testosterone; however, a neoplastic source of excess androgen was not found on imaging. Eventually, the patient revealed she was exposed to transdermal testosterone used by her partner. This case highlights the importance of considering exogenous androgens in the differential diagnosis of virilization.

article

The nucleolar channel system reliably marks the midluteal endometrium regardless of fertility status: a fresh look at an old organelle

Eli A. Rybak, Michael J. Szmyga, Gregory Zapantis, Mary Rausch, more

Fertility and Sterility > 2011 > 95 > 4 > 1385-1389.e1

To determine whether nucleolar channel systems (NCSs) in the midluteal endometrium are associated with overall fertility status and/or with unexplained infertility.Retrospective and prospective clinical studies.Repository of stored specimens from prior multicenter study and private infertility center.Retrospective study that included 97 women (49 fertile couples, 48 infertile couples) who had been...

article

Reply of the Authors

Orhan Bukulmez, Bruce R. Carr, Kevin J. Doody

Fertility and Sterility > 2011 > 95 > 1 > e6

article

Abdominal myomectomy—a safe procedure in an ambulatory setting

Robin L. Thomas, Nurit Winkler, Bruce R. Carr, Kathleen M. Doody, more

Fertility and Sterility > 2010 > 94 > 6 > 2277-2280

To evaluate the efficacy and safety of minilaparotomy myomectomy in an ambulatory setting.Retrospective, nonrandomized study.Center for Assisted Reproduction, Bedford, Texas.One hundred eighty-nine women desiring fertility with symptomatic uterine leiomyomata.Minilaparotomy myomectomy in an ambulatory setting.Operative time, blood loss, recovery time, postoperative analgesia, and complications.The...

article

Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells

Nurit Winkler, Orhan Bukulmez, Daniel B. Hardy, Bruce R. Carr

Fertility and Sterility > 2010 > 94 > 5 > 1832-1839

To investigate the effects of a gonadotropin-releasing hormone antagonist (GnRH-ANT) on the expression of anti-Müllerian Hormone (AMH) and aromatase (via the exon CYP19IIa promoter), in cultured human granulosa cells (hGCs) and the human granulosa cell line (HGL5).Primary cell cultures of hGCs and culture of HGL5 cells.Academic center.Women undergoing IVF because of male factor, tubal infertility,...

article

Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development–Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial

Kelly Pagidas, Sandra A. Carson, Peter G. McGovern, Huiman X. Barnhart, more

Fertility and Sterility > 2010 > 94 > 4 > 1444-1446

To investigate the relationship among intercourse compliance, ovulation, and the occurrence of pregnancy in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMNPPCOS) Trial.Post hoc data analysis of subjects in the Reproductive Medicine Network PPCOS Trial.Academic medical centers.None.Six hundred twenty-six infertile women with polycystic ovary syndrome with a mean age...

article

Body mass index and intercourse compliance

Kelly Pagidas, Sandra A. Carson, Peter G. McGovern, Huiman X. Barnhart, more

Fertility and Sterility > 2010 > 94 > 4 > 1447-1450

To investigate the relationship between body mass index and intercourse compliance in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMN PPCOS) Trial.Post hoc data analysis of subjects in the RMN PPCOS Trial.Academic medical centers.None.Six hundred twenty-six infertile women with polycystic ovary syndrome (PCOS) with a mean age of 28.1 ± 4 years and mean body mass index...

article

Repetitive oocyte donation does not decrease serum anti-Müllerian hormone levels

Orhan Bukulmez, Qin Li, Bruce R. Carr, Benjamin Leader, more

Fertility and Sterility > 2010 > 94 > 3 > 905-912

To determine if the anti-Müllerian hormone (AMH), a proposed marker of ovarian aging, decreases with repetitive oocyte donation.Retrospective cohort.Academic.Thirty-six young women who underwent three to seven oocyte donation cycles.Assessor blind determination of AMH levels from serum samples collected during each treatment cycle.Cycle trends of serum AMH levels.The AMH was the only predictor of...

article

Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women

David F. Archer, Vivian Lewis, Bruce R. Carr, Sophie Olivier, more

Fertility and Sterility > 2009 > 92 > 3 > 1039-1044

To evaluate the effect of bazedoxifene/conjugated estrogens (BZA/CE), a tissue selective estrogen complex, on uterine bleeding in postmenopausal women.International, multicenter, randomized, double-blind, placebo- and active-controlled, phase III study (Selective estrogen Menopause And Response to Therapy [SMART]-1).Outpatient clinical.Healthy, postmenopausal women (N = 3,397) aged 40 to 75 years...

article

Virilization persists in a woman with an androgen-secreting granulosa cell tumor

Satin S. Patel, Kelley S. Carrick, Bruce R. Carr

Fertility and Sterility > 2009 > 91 > 3 > 933.e13-933.e15

To report a case of a woman who presented with amenorrhea and masculinization secondary to an androgen-secreting granulosa cell (GC) tumor, with refractory masculinization.Case report.University medical center.A 45-year-old woman with abrupt onset of virilization with high serum androgen levels.Exploratory laparotomy with full staging.Surgical findings and histopathologic observations are included...

article

The farnesoid X receptor regulates transcription of 3β-hydroxysteroid dehydrogenase type 2 in human adrenal cells

Yewei Xing, Karla Saner-Amigh, Yasuhiro Nakamura, Margaret M. Hinshelwood, more

Molecular and Cellular Endocrinology > 2009 > 299 > 2 > 153-162

Recent studies have shown that the adrenal cortex expresses high levels of farnesoid X receptor (FXR), but its function remains unknown. Herein, using microarray technology, we tried to identify candidate FXR targeting genes in the adrenal glands, and showed that FXR regulated 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2) expression in human adrenocortical cells. We further demonstrated that FXR...

article

Medication adherence and treatment success in the National Institute of Child Health and Human Development–Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Peter G. McGovern, Sandra A. Carson, Huiman X. Barnhart, Evan R. Myers, more

Fertility and Sterility > 2008 > 90 > 4 > 1283-1286

We investigated whether poor adherence with metformin tablets may have contributed to the poor success rates seen in the metformin-containing arms of the Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial. Median adherence for both metformin and clomiphene citrate tablets was within acceptable limits and unrelated to ovulation: thus, failure to comply with physician recommendations for metformin...

article

Serum cetrorelix concentrations do not affect clinical pregnancy outcome in assisted reproduction

Orhan Bukulmez, Bruce R. Carr, Kathleen M. Doody, Kevin J. Doody

Fertility and Sterility > 2008 > 89 > 1 > 74-83

To analyze the potential association between serum cetrorelix levels and clinical pregnancy outcome in patients who had undergone assisted reproduction cycles with a GnRH antagonist cetrorelix acetate 3-mg injection.Retrospective case–control study.University-affiliated private-assisted reproduction center.130 IVF and intracytoplasmic sperm injection first cycles, treated with the same cetrorelix...

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INFONA - science communication portal

Search results for: Bruce R. Carr

Impact of body mass index on levels of soluble interleukin-6 receptor in follicular fluid of women undergoing in-vitro fertilization

Metformin for the Treatment of Polycystic Ovary Syndrome (PCOS)

Regulation of FOXO3 subcellular localization by Kit ligand in the neonatal mouse ovary

Familial 46,XY sex reversal without campomelic dysplasia caused by a deletion upstream of the SOX9 gene

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Predictive value of postwashed total progressively motile sperm count using CASA estimates in 6871 non-donor intrauterine insemination cycles

Expression and activation of the membrane-cytoskeleton protein ezrin during the normal endometrial cycle

Virilization from partner's use of topical androgen in a reproductive-aged woman

The nucleolar channel system reliably marks the midluteal endometrium regardless of fertility status: a fresh look at an old organelle

Reply of the Authors

Abdominal myomectomy—a safe procedure in an ambulatory setting

Gonadotropin releasing hormone antagonists suppress aromatase and anti-Müllerian hormone expression in human granulosa cells

Intercourse compliance, ovulation, and treatment success in the National Institute of Child Health and Human Development–Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (PPCOS) Trial

Body mass index and intercourse compliance

Repetitive oocyte donation does not decrease serum anti-Müllerian hormone levels

Bazedoxifene/conjugated estrogens (BZA/CE): incidence of uterine bleeding in postmenopausal women

Virilization persists in a woman with an androgen-secreting granulosa cell tumor

The farnesoid X receptor regulates transcription of 3β-hydroxysteroid dehydrogenase type 2 in human adrenal cells

Medication adherence and treatment success in the National Institute of Child Health and Human Development–Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome Trial

Serum cetrorelix concentrations do not affect clinical pregnancy outcome in assisted reproduction

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