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ABSTRACT
INTRODUCTIONIn order to obtain detailed information on disease‐associated changes in the integrity of cerebral white matter (WM), complementary image analysis (CIA) was applied to patients with amyotrophic lateral sclerosis (ALS) and controls.
METHODSBoth diffusion tensor imaging and T1‐weighted 3‐dimensional data were analyzed with respect to WM microstructure and T1 signal intensity alterations, respectively, in a sample of 19 ALS patients. Covariate information was added in the form of clinical parameters. All results were obtained in one common analysis software environment (Tensor Imaging and Fiber Tracking)....
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