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22(R)‐hydroxycholesterol (22(R)‐HCHO) is a crucial precursor of steroids biosynthesis with various biological functions. However, the production of 22(R)‐HCHO is expensive and unsustainable due to chemical synthesis and extraction from plants or animals. This study aimed to construct a microbial cell factory to efficiently produce 22(R)‐HCHO through systems metabolic engineering. First, we tested...
Ursolic acid (UA) is a ursane‐type pentacyclic triterpenoid compound, naturally produced in plants via specialized metabolism and exhibits vast range of remarkable physiological activities and pharmacological manifestations. Owing to significant safety and efficacy in different medical conditions, UA may serve as a backbone to produce its derivatives with novel therapeutic functions. This review aims...