Search results for: Atsushi Enomoto

Items from 1 to 20 out of 84 results

article

Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis

Toshikazu Ishihara, Katsuhiro Kato, Kotaro Matsumoto, Miyako Tanaka, more

Identifying specific markers of adipose stem and progenitor cells (ASPCs) in vivo is crucial for understanding the biology of white adipose tissues (WAT). PDGFRα‐positive perivascular stromal cells represent the best candidates for ASPCs. This cell lineage differentiates into myofibroblasts that contribute to the impairment of WAT function. However, ASPC marker protein(s) that are functionally crucial...

article

Optimal treatments and outcome measures of palmoplantar pustulosis: A systematic review and network meta‐analysis‐based comparison of treatment efficacy

Takemichi Fukasawa, Takashi Yamashita, Atsushi Enomoto, Asako Yoshizaki‐Ogawa, more

Journal of the European Academy of Dermatology and Venereology > 38 > 2 > 281 - 288

Few studies have made direct comparisons between treatments for palmoplantar pustulosis (PPP); therefore, it is difficult to select the best treatment for each patient. To determine the best therapy and to compare reported measures of efficacy in clinical trials of systemic treatments for PPP in this systematic review and network meta‐analysis. Six databases were used to perform database search on...

article

Substrate stiffness induces nuclear localization of myosin regulatory light chain to suppress apoptosis

Katsuya Onishi, Seiichiro Ishihara, Masayuki Takahashi, Akihiro Sakai, more

FEBS Letters > 597 > 5 > 643 - 656

Stiffness of the extracellular matrix regulates various biological responses, but the response mechanisms are poorly understood. Here, we found that the nuclear diphosphorylated myosin regulatory light chain (2P‐MRLC) is a critical mechanomediator that suppresses apoptosis in response to substrate stiffness. Stiff substrates promoted the nuclear localization of 2P‐MRLC. Zipper‐interacting protein...

article

Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer

Ryosuke Ichihara, Yukihiro Shiraki, Yasuyuki Mizutani, Tadashi Iida, more

Pathology International > 72 > 3 > 161 - 175

Cancer‐associated fibroblasts (CAFs), a compartment of the tumor microenvironment, were previously thought to be a uniform cell population that promotes cancer progression. However, recent studies have shown that CAFs are heterogeneous and that there are at least two types of CAFs, that is, cancer‐promoting and ‐restraining CAFs. We previously identified Meflin as a candidate marker of cancer‐restraining...

article

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity

Akitoshi Hara, Katsuhiro Kato, Toshikazu Ishihara, Hiroki Kobayashi, more

Genes to Cells > 26 > 7 > 495 - 512

Mesenchymal stem cells (MSCs) are the likely precursors of multiple lines of mesenchymal cells. The existence of bona fide MSCs with self‐renewal capacity and differentiation potential into all mesenchymal lineages, however, has been unclear because of the lack of MSC‐specific marker(s) that are not expressed by the terminally differentiated progeny. Meflin, a glycosylphosphatidylinositol‐anchored...

article

CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis

Shinji Mii, Atsushi Enomoto, Yukihiro Shiraki, Tetsuro Taki, more

Pathology International > 69 > 5 > 249 - 259

CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein and a member of the α₂‐macroglobulin/C3,C4,C5 family of thioester‐containing proteins first identified as being expressed on blood cells, including activated T cells and platelets, and a subset of CD34 ⁺ bone marrow cells containing megakaryocyte progenitors. Although CD109 carries the biallelic platelet‐specific alloantigen Gov, the physiological...

article

CD109 deficiency induces osteopenia with an osteoporosis‐like phenotype in vivo

Shinji Mii, Akiyoshi Hoshino, Atsushi Enomoto, Yoshiki Murakumo, more

Genes to Cells > 23 > 7 > 590 - 598

Osteoporosis is a global public health problem that is increasing along with an aging population. A major determinant of osteoporosis is high bone turnover, which results from osteoclast activation. CD109 is a glycosylphosphatidylinositol‐anchored glycoprotein, a deficiency that leads to a psoriasis‐like skin inflammation in mice. Although the expression of CD109 has been reported in mouse pre‐osteoclast...

article

Three‐dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae

Takuma Iwasaki, Eiki Yamashita, Atsushi Nakagawa, Atsushi Enomoto, more

Genes to Cells > 23 > 7 > 528 - 536

Tailed bacteriophages (Caudovirales) are divided into three families: Myoviridae with long contractile tails, Siphoviridae with long noncontractile tails and Podoviridae with short noncontractile tails. All have an icosahedral head with a portal vertex connected to a neck structure followed by a tail. Bacteriophage Mu belongs to the Myoviridae family. Herein, the gp29 portal subunit and neck subunits...

article

Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note

Kaori Ushida, Naoya Asai, Kozo Uchiyama, Atsushi Enomoto, more

Pathology International > 68 > 4 > 241 - 245

Embedding of tissue samples that maintains a desired orientation is critical for preparing sections suitable for diagnosis and study objectives. Methods to prepare tissue sections include: (i) paraffin embedding or snap‐freezing followed by microtome or cryostat sectioning; and (ii) agarose embedding followed by cutting on a vibrating microslicer. Although these methods are useful for routine laboratory...

article

Critical role of rabphilin‐3A in the pathophysiology of experimental lymphocytic neurohypophysitis

Yoshinori Yasuda, Shintaro Iwama, Atsushi Kiyota, Hisakazu Izumida, more

The Journal of Pathology > 244 > 4 > 469 - 478

Autoimmune hypophysitis (AH) is thought to be an autoimmune disease characterized by lymphocytic infiltration of the pituitary gland. Among AH pathologies, lymphocytic infundibulo‐neurohypophysitis (LINH) involves infiltration of the neurohypophysis and/or the hypothalamic infundibulum, causing central diabetes insipidus resulting from insufficiency of arginine vasopressin secretion. The pathophysiological...

article

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

Yukihiro Shiraki, Shinji Mii, Atsushi Enomoto, Hiroyuki Momota, more

The Journal of Pathology > 243 > 4 > 468 - 480

In the progression of glioma, tumour cells often exploit the perivascular microenvironment to promote their survival and resistance to conventional therapies. Some of these cells are considered to be brain tumour stem cells (BTSCs); however, the molecular nature of perivascular tumour cells has not been specifically clarified because of the complexity of glioma. Here, we identified CD109, a glycosylphosphatidylinositol‐anchored...

article

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus

Maki Takagishi, Masato Sawada, Shinya Ohata, Naoya Asai, more

Cell Reports > 2017 > 20 > 4 > 960-972

Motile cilia in ependymal cells, which line the cerebral ventricles, exhibit a coordinated beating motion that drives directional cerebrospinal fluid (CSF) flow and guides neuroblast migration. At the apical cortex of these multi-ciliated cells, asymmetric localization of planar cell polarity (PCP) proteins is required for the planar polarization of microtubule dynamics, which coordinates cilia orientation...

article

Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway

Atsushi Enomoto, Junko Yamada, Akinori Morita, Kiyoshi Miyagawa

Mutation Research/Genetic Toxicology and Environmental Mutagenesis > 2017 > 815 > C > 1-5

Bisdemethoxycurcumin (BDMC), which is isolated from the rhizomes of Curcuma longa, has anti-inflammatory and anti-carcinogenic activities. Here we found that BDMC enhanced X-ray-induced apoptosis in human T-cell leukemia MOLT-4 cells. Knockdown of p53 significantly attenuated the radiosensitizing effect of BDMC. However, BDMC did not enhance X-ray-mediated activation of the p53 signaling pathway via...

article

Well‐differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration

Tokiko Nakai, Tomonori Kawasaki, Takashi Tada, Motoo Ishida, more

Pathology International > 66 > 12 > 706 - 707

article

High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway

Seiya Arita, Yuta Kinoshita, Kaori Ushida, Atsushi Enomoto, more

Archives of Biochemistry and Biophysics > 2016 > 610 > C > 16-24

Obesity increases the risk for gastric cancers. However, the occurrence and mechanisms of precancerous atrophic gastritis induced by high-fat diet (HFD) remain unclear. Here, we show that HFD-associated lipotoxicity induces precancerous lesions that are accompanied by the disruption of organelle homeostasis, tissue integrity, and deregulated expression of stemness genes in the gastric epithelium mediated...

article

Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues

Hiroyuki Makihara, Hironori Inaba, Atsushi Enomoto, Hiroki Tanaka, more

Biochemical and Biophysical Research Communications > 2016 > 478 > 3 > 1323-1329

Desmin is a type III intermediate filament (IF) component protein expressed specifically in muscular cells. Desmin is phosphorylated by Aurora-B and Rho-kinase specifically at the cleavage furrow from anaphase to telophase. The disturbance of this phosphorylation results in the formation of unusual long bridge-like IF structures (IF-bridge) between two post-mitotic (daughter) cells. Here, we report...

article

Collective invasion of cancer: Perspectives from pathology and development

Xiaoze Wang, Atsushi Enomoto, Naoya Asai, Takuya Kato, more

Pathology International > 66 > 4 > 183 - 192

Clinical pathologists have long been aware that in many types of human malignant tumors, the cells are often connected and form groups of various sizes or “nests”. In this way, they achieve “collective invasion” into the surrounding stroma, rather than spreading out individually. Such collective behavior is also a common feature of migration during embryonic and postnatal developmental stages, suggesting...

chapter

Spleen Cells Derived from Male Non-Obese Diabetic Mice are Capable of Suppressing the Autoantigen-Specific Production of Interferon-γ of Female Cells In Vitro

Atsushi Enomoto, Takumi Ohsaki, Shogo Komine, Mayuko Hasegawa

Animal Cell Technology: Basic & Applied Aspects > Animal Cell Technology: Basic & Applied Aspects > 111-115

Non-obese diabetic (NOD) mice spontaneously develop insulin-dependent diabetes mellitus with a clear female prevalence. Using Transwell co-culture systems with both female and male splenocytes, we found that spleen cells of male NOD mice suppress autoantigen (glutamic acid decarboxylase, GAD)-specific production of interferon-γ of female cells. In addition, this suppression appeared to be mediated...

chapter

Cytokine Responses of Splenocytes of Female and Male Non-Obese Diabetic Mice Induced by Lactic Acid Bacteria

Atsushi Enomoto, Mohd Azraai Bin Jamal, Hiromi Mitsui, Hiromi Kimoto-Nira, more

Animal Cell Technology: Basic & Applied Aspects > Animal Cell Technology: Basic & Applied Aspects > 365-370

It has been well recognized that the incidences of autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM) and rheumatoid arthritis (RA) are largely influenced by genetic factors [1, 2]. For example, non-obese diabetic (NOD) mice, an animal model for spontaneous IDDM, show a clear female predilection [3].

article

Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction

Shinji Hayano, Mikito Takefuji, Kengo Maeda, Tomonori Noda, more

Journal of Molecular and Cellular Cardiology > 2015 > 88 > Complete > 55-63

Myocardial infarction is a leading cause of death, and cardiac rupture following myocardial infarction leads to extremely poor prognostic feature. A large body of evidence suggests that Akt is involved in several cardiac diseases. We previously reported that Akt-mediated Girdin phosphorylation is essential for angiogenesis and neointima formation. The role of Girdin expression and phosphorylation...

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INFONA - science communication portal

Search results for: Atsushi Enomoto

Meflin/ISLR is a marker of adipose stem and progenitor cells in mice and humans that suppresses white adipose tissue remodeling and fibrosis

Optimal treatments and outcome measures of palmoplantar pustulosis: A systematic review and network meta‐analysis‐based comparison of treatment efficacy

Substrate stiffness induces nuclear localization of myosin regulatory light chain to suppress apoptosis

Matrix remodeling‐associated protein 8 is a marker of a subset of cancer‐associated fibroblasts in pancreatic cancer

Meflin defines mesenchymal stem cells and/or their early progenitors with multilineage differentiation capacity

CD109: a multifunctional GPI‐anchored protein with key roles in tumor progression and physiological homeostasis

CD109 deficiency induces osteopenia with an osteoporosis‐like phenotype in vivo

Three‐dimensional structures of bacteriophage neck subunits are shared in Podoviridae, Siphoviridae and Myoviridae

Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note

Critical role of rabphilin‐3A in the pathophysiology of experimental lymphocytic neurohypophysitis

Significance of perivascular tumour cells defined by CD109 expression in progression of glioma

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus

Bisdemethoxycurcumin enhances X-ray-induced apoptosis possibly through p53/Bcl-2 pathway

Well‐differentiated neuroendocrine tumor of the breast with extensive lymphatic and vascular infiltration

High-fat diet feeding promotes stemness and precancerous changes in murine gastric mucosa mediated by leptin receptor signaling pathway

Desmin phosphorylation by Cdk1 is required for efficient separation of desmin intermediate filaments in mitosis and detected in murine embryonic/newborn muscle and human rhabdomyosarcoma tissues

Collective invasion of cancer: Perspectives from pathology and development

Spleen Cells Derived from Male Non-Obese Diabetic Mice are Capable of Suppressing the Autoantigen-Specific Production of Interferon-γ of Female Cells In Vitro

Cytokine Responses of Splenocytes of Female and Male Non-Obese Diabetic Mice Induced by Lactic Acid Bacteria

Akt-dependent Girdin phosphorylation regulates repair processes after acute myocardial infarction

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