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A model for the evolution of mammalian cysteine proteinase inhibitors has been constructed on the basis of sequence homology. This model suggests that the diversity of cysteine proteinase inhibitors has evolved from two ancestral units forming the building blocks of stefin and cystatin. Gene triplication of the archetypal inhibitor generated the kininogen heavy chain which contains three cystatin-like...
Human high- and low-M r kininogens were shown to be potent inhibitors of cysteine proteinases such as cathepsin L and papain (K i = 17-48 pM). A strong immunological cross-reaction between the kininogens and low-M r α-cysteine proteinase inhibitor from human plasma was found. Comparison of partial amino acid sequences from high- and low-M r kininogen and low-M r...
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