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Various amide prodrugs of ketorolac were synthesized and their rat skin permeation characteristics were determined. The solubility of the prodrugs in propylene glycol (PG) was determined at 37°C while lipophilicity was obtained as 1-octanol/water partition coefficient (logP) and capacity factor (k′) using HPLC. Stability of the prodrugs in rat skin homogenate, plasma and liver homogenate was investigated...
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