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Choroidal neovascularization (CNV) in age-related macular degeneration (AMD) may results in severe vision loss. Upregulation of vascular endothelial growth factor (VEGF) in hypoxic retinal pigment epithelium (RPE), mediated by hypoxia-inducible factor 1 (HIF-1) is responsible for CNV. Hypoxia triggers ATP-deletion in RPE cells, which activates HIF-1 via the Rho GTPase. HIF-1 also activates the expression...
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