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Background: Hydroxy-methyl-glutaryl co-enzyme A reductase inhibitors (HMG CoA RIs) markedly improve the lipid profile of patients with hypercholesterolemia, but the magnitude and time course of the effect of these drugs on other risk factors for atherosclerosis are not well defined. Methods: We employed a random assignment, double-blind design to compare the effect of 8 weeks of HMG CoA RI therapy...
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