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Background and PurposeTapentadol is a novel analgesic that combines moderate μ‐opioid receptor agonism and noradrenaline reuptake inhibition in a single molecule. Both mechanisms of action are involved in producing analgesia; however, the potency and efficacy of tapentadol in individual neurons has not been characterized.
Experimental ApproachWhole‐cell patch‐clamp recordings of G‐protein‐coupled...
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