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Purpose Patupilone (EPO906) is a novel potent microtubule stabilizer, which has been evaluated for cancer treatment. A novel physiologically based pharmacokinetics (PBPK) model was developed based on nonclinical data to predict the disposition of patupilone in cancer patients. Methods After a single intravenous dose (1.2 mg/kg) in male Han–Wistar rats, the tissue distribution of 14C-patupilone was...
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