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Aim
Arteriolar hyalinosis (AH) is a common lesion in allograft biopsies taken following kidney transplantation. Recent studies have shown that severe AH may predict transplant outcomes and provide information about previous exposure to certain drugs, such as calcineurin inhibitors (CNI). However, the incidence of AH as a direct result of diabetic nephropathy (DN) after kidney transplantation has...
We previously reported that 1,2-di-O-acyl-3-O-(-d-sulfoquinovosyl)-glyceride with two stearic acids (β-SQAG9) bound to L-selectin on the cell surface of the CD62L + T-cell subset and inhibited T-cell migration into lymph nodes in a rat skin allograft model. The aim of this study was to verify the efficacy of β-SQAG9 for kidney allograft survival in miniature swine. Recipient swine underwent...
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