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Abstract We previously reported that lipopolysaccharide (LPS) injected intracerebroventricularly (i.c.v.) at an ineffective dose (0.1g/rat) decreased the drug metabolizing activities and related cytochrome P450 (CYP) isozymes in rat liver microsomes when injected intraperitoneally (i.p.). The dose study (doses 0.1g intracerebrally and 0.1g i.p.), which was carried out to examine how much more effective...
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