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Background Oral mucosal lesions develop in pemphigus vulgaris, but not in pemphigus foliaceus. This clinical phenomenon is explained by the ‘desmoglein (Dsg) compensation theory’. Dsg3 and Dsg1 are major autoantigens for pemphigus vulgaris and pemphigus foliaceus, respectively. Dsg3 is overexpressed and Dsg1 is weakly expressed on the oral mucosa. Thus, on the oral mucosa, suppression of Dsg3 function...
Background Psoriasis is associated with premature atherosclerosis although the underlying mechanism remains unclear.
Objectives We sought to investigate the relationship between disease activity and systemic inflammation in patients with psoriasis, and macrovascular and microvascular function.
Methods Fifty‐two patients with psoriasis (mean ± SD age 44 ± 8 years; 38 men) were compared with 50 age‐...
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