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Bleomycin (BLM) is a promising chemotherapeutic that causes oxidative damage to DNA resulting in cell death. However, this non-permeant drug is mainly internalized via receptor-mediated endocytosis. Therefore, tumors showing a poor expression of BLM-binding proteins are resistant to this therapy. This work aims to demonstrate the ability to improve the intracellular accumulation and efficacy of BLM...
Bleomycin (BLM) is a potent chemotherapeutic that causes cytotoxic oxidative damage to DNA. However, this non-permeant drug is mainly internalized via receptor-mediated endocytosis. Therefore, tumors showing poor expression of BLM-binding proteins are resistant to this therapy. This work aims to improve the intracellular accumulation and efficacy of BLM in resistant colorectal adenocarcinoma cells...
The mechanisms by which sonoporation increases the native plasma membrane permeability are still unknown but various hypotheses have been suggested including pore formation and endocytosis. We have shown recently that caveolae-mediated endocytosis plays a major role during sonoporation. In addition, some studies have reported the clear participation of actin in mammalian cell endocytosis. Thus, this...
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