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Objective. To determine whether pre‐ and post‐operative administration of intravenous ibuprofen (IV‐ibuprofen) can significantly decrease pain and morphine use when compared with placebo in adult orthopedic surgical patients.
Design. This was a multi‐center, randomized, double‐blind placebo‐controlled trial.
Setting. This study was completed at eight hospitals; six in the United States and two...
In this randomized, placebo-controlled, double-blind study, the efficacy and safety of rofecoxib ⁎ 50 mg was evaluated in patients undergoing major abdominal gynecologic surgery. Patients were randomized to receive rofecoxib 50 mg (n = 81) or placebo (n = 83) ∼2 hours before total abdominal hysterectomy or myomectomy and once daily over the ensuing 4 days. Clinical measurements included...
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