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The Epidermal Sensitization Assay (EpiSensA) is a reconstructed human epidermis (RhE)‐based gene expression assay for predicting the skin sensitization potential of chemicals. Since the RhE model is covered by a stratified stratum corneum, various kinds of test chemicals, including lipophilic ones and pre‐/pro‐haptens, can be tested with a route of exposure akin to an in vivo assay and human exposure...
The aim of this study is to validate an in vitro skin irritation test (SIT) using three‐dimensional reconstructed human epidermal (RhE) skin equivalents prepared by layer‐by‐layer (LbL) method (LbL‐3D Skin) in a series of interlaboratory studies. The goal of these validation studies is to evaluate the ability of this in vitro test to reliably discriminate skin irritant from nonirritant chemicals,...