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Abstract On the basis of our previous series of experiments we had postulated that the increased anxiety that occurred during diazepam withdrawal was mediated by increased 5-HT release in the hippocampus. The present series of experiments provide evidence for a major role of the median raph nucleus (MRN) dorsal hippocampal pathway. Rats were treated once daily for 21 days with diazepam (2mg/kg IP)...
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