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Multimodal brain monitoring is an important approach to gain insight into brain function, modulation, and pathology. We have developed a unique micromachined neural probe capable of real-time continuous monitoring of multiple physiological, biochemical and electrophysiological variables. However, to date, it has only been used in anesthetized animals due to a lack of an appropriate interface for awake...
In this paper, we present a flexible temperature sensor with ultra-small polysilicon thermistors for brain temperature monitoring. In vitro sensitivity, resolution, thermal hysteresis and long term stability tests were performed. Temperature coefficient of resistance (TCR) of −0.0031/ °C and resolution of 0.1 °C were obtained for the sensor. Thermal hysteresis for temperature range of 30∼45 °C was...
A novel lab-on-a-tube (LOT) integrated with spirally-rolled pressure, temperature, oxygen and glucose microsensors has been designed, fabricated, and characterized for multimodal neuromonitoring of patients with traumatic brain injury and other acute neurosurgical and neurological disorders. While it is capable of measuring various crucial physiological parameters in real-time continuous formats,...
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