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Antiallergic drugs and antihistamines have been widely used for controlling mucosal allergic diseases in which eosinophilia is prominent. Although H1-receptor antagonists are effective for treating histamine-induced wheal and itch in urticaria, the effects of antihistamines and antiallergic agents on other eosinophilic skin diseases remain to be determined. We investigated the effects of oral administration...
Background: Eotaxin plays a central role in the development of allergic diseases such as atopic dermatitis (AD), asthma, and nasal allergy because it acts as a chemoattractant for eosinophils in allergic inflammation. The inflammatory cytokines interleukin (IL)-4, tumor necrosis factor-alpha, and IL-13 have been reported to enhance eotaxin production synergistically in normal human fibroblasts. Histamine...
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