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4-Hydroxyisoleucine (4-HIL) is an unusual amino acid isolated from fenugreek seeds (Trigonella foenum graecum L). Various studies have shown that it acts as an antidiabetic agent yet its mechanism of action is not clear. We therefore investigated the effect 4-HIL on the high fructose diet fed streptozotocin induced diabetic rats and L6 myotubes. 4-HIL (50mg/kg) has improved blood lipid profile, glucose...
Antihyperglycaemic effect of the crude extract (1) and four fractions (2, 3, 4, and 5) of Ceriops tagal (Perr.) C.B. Rob. (Rhizophoraceae) were evaluated in normal healthy sucrose-loaded and STZ-induced diabetic rats. The crude extract improved the glucose tolerance of the sucrose-loaded rats significantly (p < 0.05) with 33.2% activity, while in STZ-induced diabetic rats the extract caused a fall...
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