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In this study, we investigated ILK expression in myeloma cell lines U266 and H929 kept in suspension and cocultured with BMSCs, and studied the pharmacologic inhibitors of ILK on the apoptosis, invasive potential of myeloma cell lines, and production of pro-angiogenic factors of bone marrow stromal cells. We found that ILK protein was expressed in U266 and H929 cells and kinase activity was elevated...
We studied the mechanisms involved in the drug resistance of C6/ADR and compared the reversal effects of XIAP and MDR1 ASO used in combination and separately. Reverse transcription-PCR and Western blot were applied to detect the mRNA and protein levels, respectively. The results showed that XIAP and MDR1 ASO used separately could down-regulate the levels of XIAP and MDR1 in C6/ADR cells, respectively...
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