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Purpose. To construct an EGF receptor (EGF-R)-mediated histone H10-based gene delivery system for gene therapy. Methods. A recombinant DNA containing histone H10, EGF-R ligand, and endosomalytic domains was constructed in a prokaryotic vector and expressed in E. coli. Expression of the -galactosidase (-gal) gene in the tumor cells and tissues was observed after transduction of the -gal gene packaged...
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