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Insulin sensitivity is decreased by prostaglandin E 2 (PGE 2 ), a major product of cyclooxygenase (COX). As shown in erythrocytes, PGE 2 formation is inhibited by annexin A7. The present study defined the role of annexin A7 in glucose metabolism. Gene-targeted mice lacking annexin A7 ( annexin7−/− ) were compared to wild-type mice ( ...
Amyloid peptides interfere with survival of pancreatic beta-cells. In some cells apoptosis is paralleled by ceramide-dependent alterations of ion channel activity. The purpose of the present study was to elucidate the dependence of amyloid peptides Aß1-42 and islet amyloid polypeptide (IAPP)-induced cell death on ceramide formation and ion channel activity in murine pancreatic islet cells. As disclosed...
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