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The synthesis of 47 structurally diverse compounds incorporating the (R)-2-amino-1-butanol motif has been realized. Ten of these compounds were found to exhibit in vitro specific activity against Mycobacterium tuberculosis H37Rv in a MIC range of 0.65 μM–14.03 μM. Five of the most active compounds 11, 22, 23, 31 and 42 (5.7–11.1 fold more active than ethambutol) can be outlined with very low cytotoxicity...
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