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Rationale Treating children and adolescents with partial D2-like agonists is becoming increasingly common, although few developmental animal studies have assessed the psychopharmacology of this class of drug. Contrary to results from adult rat studies, it has been reported that partial D2-like agonists may not induce agonist-like behavioral effects in preweanling rats during states of low dopaminergic...
Rationale In adult rats, the partial D2-like agonist terguride acts as an antagonist at normosensitive D2-like post-synaptic receptors, while it acts as an agonist at the same receptors during states of low dopaminergic tone. Objective The purpose of the present study was to determine whether partial D2-like agonists exhibit both antagonistic and agonistic actions during the preweanling period. Methods...
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