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β-lactamases are the most widespread resistance mechanisms to β-lactam antibiotics, and there is a pressing need for novel, non-β-lactam drugs. A database of over 200,000 compounds was docked to the active site of AmpC β-lactamase to identify potential inhibitors. Fifty-six compounds were tested, and three had K i values of 650 μM or better. The best of these, 3-[(4-chloroanilino)sulfonyl]thiophene-2-carboxylic...
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