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Cells are equipped with a host of receptors that can convert chemical signals into electrical ones. Cell-based biosensors take cells as sensing elements for detecting the intracellular/extracellular microenvironment and some special characteristics of cells selves. This paper presents the design of the cell-based biosensor and optimization of the automatic fluidic system that makes it feasible to...
Olfactory system can distinguish thousands of odors. In order to utilize biological olfactory neurons as sensitive material of electronic nose, this article reports an olfactory neurochip as real bionic technique for odorants detection. Effective cultures of olfactory receptor neurons and olfactory bulb cells on the chip have been achieved. Using light-addressable potentiometric sensor (LAPS) as sensing...
A novel numerical design of experimental analysis of cell-based sensors was introduced in the paper. In order to increase the signals to noise ratio and improve the performance of the chips, we analyzed cell-based sensors numerically and experimentally. Since the action potential which is about dozens of milliseconds changes quickly, we demonstrated an improved equivalent circuit model. Based on modeling...
Cell-based biosensors incorporate cells as sensing elements that convert a change in immediate environment to signals conducive for processing. It characterizes with high sensitivity, excellent selectivity and fast response. Cell-based biosensors have been implemented for a number of applications ranging from pharmaceutical screening to environmental pollutant detection. This work demonstrate a novel...
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