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ObjectivesMyostatin, a member of the transforming growth factor‐β superfamily, is a negative regulator of myogenesis in skeletal muscle. We examined the effect of myostatin and myostatin inhibition by an antagonistic agent, follistatin, on growth of human urethral rhabdosphincter satellite cells (muscle stem cells) to develop a new strategy for treatment of stress urinary incontinence.
MethodsRhabdosphincter...
BACKGROUNDStem‐cell injection into the degenerated external urethral sphincter is a new treatment modality for stress urinary incontinence (SUI). We examined the possibility of long‐term cryopreserved pyramidalis muscle (PM) specimens as a source of striated muscle stem cells for the treatment of post‐prostatectomy SUI.
METHODSPM specimens were obtained from five male patients (mean age, 61–70 years)...
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