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There are a wide variety of spectrophotometric devices nowadays used in health services with various qualities of manufacture methods of measurement and metrological characteristics for performing the necessary measurements. Therefore, to meet the accuracy and repeatability requirements needed in medical diagnosis and treatment, the validation of the performance of such systems by clinical chemistry...
In the present study, new isocratic stability-indicating reverse phase chromatographic methods were developed using HPLC and UPLC systems for the determination of entacapone (ENT) in its pharmaceutical dosage forms. Ultra performance liquid chromatography (UPLC) using small sub-2 μm particles and high-performance liquid chromatography (HPLC) were compared for separation and determination of the ENT...
The natural methyl donor group, S-adenosylmethionine and its product, S-adenosylhomocysteine play an important role in many biochemical reactions involving transmethylation reactions. These compounds can be used as biomarkers in incipient diagnosis of various pathological disorders therefore the validation of a suitable method to routinely analysis of these compounds is very important. In this paper,...
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