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Two pyridoacridines, N-hydroxymethylisocystodamine (1) and neolabuanine A (2), together with the known ecionine A (3), ecionine B (4), isocystodamine (5), N-methylisocystodamine (6), 9-hydroxyisoascididemin (7), and biemnadin (8), were isolated from a marine sponge Biemna sp. Several of these compounds were shown to induce cell differentiation of K562 leukemia cells into erythrocytes. Following inspection...
Two pyridoacridines closely related to the known isocystodamine were isolated from the marine sponge Biemna sp. together with isocystodamine. Their structures were determined on the basis of spectroscopic data. They induce the erythroid differentiation of human leukemia K562 cells with an ED 50 value of 5 nM each.
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