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Effects of gangliosides GM3, GD3 and GT1b on protein kinase C (PKC) activity and endogenous protein phosphorylation by PKC were examined in bovine mammary gland. The gangliosides inhibited PKC activity in both cytosolic and total particulate fractions with IC 50 values (concentrations causing 50% inhibition) of 100-115 μM (GM3), 75-80 μM (GD3) and 20-28 μM (GT1b). Several proteins were...
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