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In order to understand the information encoded by DNA sequences, databases containing large amount of DNA sequence information are frequently compared and searched for matching or near-matching patterns. This kind of similarity calculation is known as sequence alignment. To date, the most popular algorithms for this operation are heuristic approaches such as BLAST and FASTA which give high speed but...
A 16-channel chip for wireless in vivo recording of chemical and electrical neural activity is described. The 7.83-mm2 IC is fabricated using a 0.5-mum CMOS process and incorporates a 71-muW, 3rd-order, configurable, DeltaSigma modulator per channel, achieving an input-referred noise of 4.69 muVrms in 4-kHz BW and 94.1 pArms in 5-kHz BW for electrical and fast-scan voltammetric chemical neurosensing,...
Deep brain stimulation (DBS) of the thalamus is widely used in humans to treat essential tremor and tremor dominant Parkinson's disease. After DBS lead implantation, tremor is often reduced even without electrical stimulation. Often called ldquomicrothalamotomyrdquo effect, the exact mechanism is unknown, although it is presumed to be due to micro lesioning. Here, we tested whether microthalamotomy...
The Wireless Instantaneous Neurotransmitter Concentration Sensing System (WINCS) measures extracellular neurotransmitter concentration in vivo and displays the data graphically in nearly real time. WINCS implements two electroanalytical methods, fast-scan cyclic voltammetry (FSCV) and fixed-potential amperometry (FPA), to measure neurotransmitter concentrations at an electrochemical sensor, typically...
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