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One of the two receptors by which the potent vasoactive effects of endothelin (ET)-1 are mediated is the ET B receptor (ET BR ), which is found in several tissues, but, more importantly from a cardiovascular point of view, on the endothelial cell. The endothelial cell also has the unique capability of releasing ET-1, as well as other factors, such as the endothelial-derived relaxing...
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