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Patients with sickle cell anemia (SCA) experience cerebral metabolic stress with an increase in oxygen extraction fraction (OEF) to compensate for reduced oxygen carrying capacity due to anemia. It remains unclear if anemia alone drives this metabolic stress. Using MRI, we collected voxel‐wise OEF measurements to test our hypothesis that OEF would be elevated in anemic controls without SCA (AC) compared...
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