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The tetrahydroisoquinoline trabectedin is a marine compound with approved activity against human soft‐tissue sarcoma. It exerts antiproliferative activity mainly by specific binding to the DNA and inducing DNA double‐strand breaks (DSB). As homologous recombination repair (HRR)‐deficient tumors are more susceptible to trabectedin, hyperthermia‐mediated on‐demand induction of HRR deficiency represents...
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