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A variety of structurally novel phosphoalkoxy ester derivatives were prepared via highly regio- and diastereoselective four-component reaction involving olefin, cyclic ether, halogen reagent and organic phosphate. All components can be varied flexibly and moderate to excellent yields were obtained at room temperature. Several of these ester derivatives showed strong anticancer activity against human...
A novel and highly regio- and diastereoselective four-component reaction involving an olefin, a cyclic ether, a halogen reagent, and a sulfonic acid has been developed to access alkoxyether derivatives. Moderate to excellent yields were obtained with a broad substrate scope without external catalyst. Several of these sulfonate ester derivatives showed strong anticancer activity against human lung...
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