The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Serotonin (5-HT) and its receptors play a multifaceted role in pain modulation. Among the many subtypes of 5-HT receptors potentially contributing to medullo-spinal modulation of pain, 5-HT1A and 5-HT7 receptors have significant role, as it is expressed both in supraspinal and spinal areas. A series of newly synthesized 3,3-disubstituted pyrrolidine-2,5-diones with affinity for 5-HT1A and 5-HT7 receptors...
Marble burying test (MBT) is an animal model of anxiety and obsessive-compulsive disorder, used as a screening test for new compounds in modern drug development. The aim of this study was to introduce that method to experimental workshop of the Clinical Pharmacy Department. MBT was carried out according to the procedure of Broekkamp et al. (1986). The first stage of the work was to determine the relevant...
ADN-1319 is a new indoloamine analogue of aripiprazole which displays antipsychotic-like properties in mouse models of psychosis, i.e. MK-801- and amphetamine-induced locomotor hyperactivity. In order to examine its potential antidepressant and anxiolytic activity, the forced swim test, and the four-plate and the marble burying tests, respectively, in mice were performed and a minimum effective dose...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.