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J wave syndromes are a collection of clinical entities characterized by accentuation of the Ito-mediated J wave, early repolarization and ST segment elevation. Although the risks of sudden cardiac death of these syndromes differ with respect to the magnitude and location of abnormal J wave manifestation and ST segment elevation, they share with a common ionic and cellular mechanism and their responses...
Short QT Syndrome is a recently recognized inherited channelopathy responsible for sudden cardiac death (SCD) in individuals with a structurally normal heart. It is characterized by abnormally short QTc interval (<360 msec) on the electrocardiogram seen in conjunction with a family history of atrial and/or ventricular fibrillation. It is a genetically heterogeneous disease with mutations in five...
Quinidine is used to treat atrial fibrillation and ventricular arrhythmias. However, at low concentrations, it can induce torsade de pointes (TdP).The purpose of this study was to examine the role of late sodium current (I Na ) as a modulator of the arrhythmogenicity of quinidine in female rabbit isolated hearts and cardiomyocytes.Epicardial and endocardial monophasic action potentials (MAPs),...
The Brugada syndrome is characterized by ST-segment elevation in the right precordial leads, V 1 –V 3 (unrelated to ischemia or structural disease), normal QT intervals, RBBB pattern, and sudden cardiac death, particularly in men of Asian origin. An autosomal dominant mode of inheritance with variable penetrance is generally observed. The only gene mutations thus far linked to the...
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