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Increased presence of circulating DNA has been reported in lung cancer. However, the utility of circulating DNA as a diagnostic and prognostic marker and in assessing therapeutic efficacy is yet to be realized.Circulating plasma DNA levels were quantified in 100 patients with non-small cell lung cancer and 100 age-matched controls. Forty-two patients received platinum-based chemotherapy for a minimum...
Accumulating evidence suggests a change in cytokine profile after cytotoxic therapies. We hypothesized that change in plasma levels of tumor necrosis factor-alpha (TNF-α) during the course of chemotherapy in lung cancer may predict therapeutic efficacy at an early stage.Plasma TNF-α levels were quantified before first, second, and third cycle of chemotherapy in 42 patients with advanced non-small...
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