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Asymptomatic infants and infants with gastroesophageal reflux have been noted to have peak reflux in the midafternoon. The aim of this study was to examine circadian variation of gastroesophageal reflux in children with both normal and abnormal 24-hr esophageal pH probe studies. Eighty-seven patients were studied and 15 of these patients were found to have a reflux index >4% for the duration of...
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