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Severe inflammation and myogenic differentiation disorder are the major obstacles to skeletal muscle healing after injury. MicroRNAs (miRNAs) play an important role as regulatory molecules during the process of muscle healing, but the detailed mechanism of miRNA‐mediated intercellular communication between myoblasts and macrophages remains unclear. Here, it is reported that myoblasts secrete miRNAs‐enriched...
Macrophage Polarization
In article number 2201957, Xiliang Shang, Shiyi Chen, Jiwu Chen, and co‐workers find that myoblast‐derived exosomes modulate macrophage polarization and contribute to muscle fibrosis within the post‐injury inflammatory environment, while the miRNA inhibitor‐loaded liposomes brake the vicious circle, induce M2 polarization, relieve the inflammatory response, and promote the...
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